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Get Free AccessOnset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n=4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P(adj) =0.0067; odds ratio=1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.
Sylvane Desrivières, Anbarasu Lourdusamy, Christian P. Müller, Francesca Ducci, Cybele P. Wong, Marika Kaakinen, Anneli Pouta, Anna‐Liisa Hartikainen, Matti Isohanni, Pimphen Charoen, Leena Peltonen, Nelson Freimer, Paul Elliott, Paul M Ridker, Günter Schumann (2010). Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents. , 16(3), DOI: https://doi.org/10.1111/j.1369-1600.2010.00239.x.
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Type
Article
Year
2010
Authors
15
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1111/j.1369-1600.2010.00239.x
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