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Get Free AccessEstimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites.
Amol C. Shetty, Christopher G. Jacob, Fang Huang, Yao Li, Sonia Agrawal, David Saunders, Chanthap Lon, Mark M. Fukuda, Pascal Ringwald, Elizabeth A. Ashley, Kay Thwe Han, Tin Maung Hlaing, Myaing M. Nyunt, Joana C. Silva, Kathleen Stewart, Christopher V. Plowe, Timothy D. O’Connor, Shannon Takala‐Harrison, Harald Noedl, Wasif Ali Khan, Paul N. Newton, Myat Phone Kyaw, Sir Nicholas White, Arjen M. Dondorp, Nicholas Day, Charles J. Woodrow, Mehul Dhorda, Maryam Faiz, Rick M. Fairhurst, Pharath Lim, Rupam Tripura, Mayfong Mayxay, Ye Htut, François Nosten, Aung Pyae Phyo, Sasithon Pukrittayakamee, Tran Tinh Hien, Thuy-Nhien Nguyen, Olugbenga Ayodeji Mokuolu, Caterina Fanello, Marie Onyamboko (2019). Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns. Nature Communications, 10(1), DOI: 10.1038/s41467-019-10121-3.
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Type
Article
Year
2019
Authors
41
Datasets
0
Total Files
0
Language
English
Journal
Nature Communications
DOI
10.1038/s41467-019-10121-3
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