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Get Free AccessFew genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
Ken K. Ong, Blair H. Smith, Barbara McKnight, Louis Pérusse, Hans J. Grabe, Pedro Marques‐Vidal, Jaspal S. Kooner, Nicholas J. Wareham, Andrew P. Morris, Tanja B. Grammer, Martina Chittani, Maija Hassinen, Stella Trompet, Markus Juonala, Charles Kooperberg, Annette Peters, Joseph C. Wu, Johanna Kuusisto, M. Carola Zillikens, Marcel Bruinenberg, Anna L. Eriksson, Ani Manichaikul, Caroline S. Fox, Harold Snieder, Llilda Barata, Henrik Vestergaard, Ozren Polašek, Ingrid B. Borecki, Nicholas G. Martin, Tarunveer S. Ahluwalia, Naveed Sattar, Dan Mellström, Paul W. Franks, Joel N. Hirschhorn, Heather M. Stringham, Mika Kivimäki, Paul M Ridker, Francesco Cucca, Audrey Y. Chu, Lynne J. Hocking, Oddgeir L. Holmen, Tanguy Corre, Reija Männikkö, J. Wouter Jukema, Jaakko Tuomilehto, Gerard Pasterkamp, Bruce H. R. Wolffenbuttel, Dena Hernández, Anthony James, Ian Ford, Iris M. Heid, Inês Barroso, Rajesh Rawal, Najaf Amin, Catharina A. Hartman, Bamidele O. Tayo, Karl Gertow, Neşe Direk, Mattias Lorentzon, Tõnu Esko, Joel Eriksson, Saima Afaq, Cornelia M. van Duijn, Mélanie Waldenberger, Beverley Balkau, Jian Ping Gong, Natalia Pervjakova, Kristin L. Young, Damiano Baldassarre, Loïc Yengo, Anne E. Justice, Jian’an Luan, Alexander Teumer, Bruna Gigante, Momoko Horikoshi, Lenore J. Launer, Harald Grallert, Julius S. Ngwa, Ying Wu, Anja Ludolph-Donislawski, Rao , Dorothée Thuillier, Frida Renström, Lucia A. Hindorff, Peter S. Chines, Stéphane Lobbens, Stavroula Kanoni, Martina Müller‐Nurasyid, John‐Olov Jansson, Pau Navarro, Eco J. C. de Geus, Lynda M. Rose, Kai Savonen, Unhee Lim, David J. Hunter, Cinzia Sarti, Lawrence F. Bielak, Rainer Rauramaa, John B. Whitfield, Nicholas D. Hastie (2020). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. , DOI: https://doi.org/10.17615/55b7-9477.
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Type
Article
Year
2020
Authors
100
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.17615/55b7-9477
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