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Get Free AccessThese genome-wide association study support the importance of DDAH1 and MED23/Arg1 in regulating ADMA and l-arginine metabolism, respectively, and identify a novel regulatory renal pathway for SDMA by AGXT2. AGXT2 variants might explain part of the pathogenic link between SDMA, renal function, and outcome. An association between AGXT2 variants and stroke is unclear and warrants further investigation.
Nicole Lüneburg, Wolfgang Lieb, Tanja Zeller, Ming‐Huei Chen, Renke Maas, Angela M. Carter, Vanessa Xanthakis, Nicole L. Glazer, Edzard Schwedhelm, Sudha Seshadri, M. Arfan Ikram, W.T. Longstreth, Myriam Fornage, Inke R. König, Christina Loley, Francisco Ojeda, Arne Schillert, Thomas J. Wang, Heinrich Sticht, Anja Kittel, Jörg König, Emelia Benjamin, Lisa Sullivan, Isabel Bernges, Maike Anderssohn, Andreas Ziegler, Christian Gieger, Thomas Illig, Christa Meisinger, H.‐Erich Wichmann, Philipp S. Wild, Heribert Schunkert, Bruce M. Psaty, Kerri L. Wiggins, Susan R. Heckbert, Nicholas L. Smith, Karl J. Lackner, Kathryn L. Lunetta, Stefan Blankenberg, Jeanette Erdmann, Thomas Münzel, Peter J. Grant, Ramachandran S. Vasan, Rainer H. Böger (2014). Genome-Wide Association Study of <scp>l</scp> -Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine. , 7(6), DOI: https://doi.org/10.1161/circgenetics.113.000264.
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Type
Article
Year
2014
Authors
44
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1161/circgenetics.113.000264
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