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Get Free AccessMigraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine.We performed a genome-wide association analysis contrasting 460 bipolar migraneurs with 914 bipolar patients without migraine from the Bipolar Genome Study (BiGS).We identified one genome-wide significant association between migraine in bipolar disorder patients and rs1160720, an intronic single nucleotide polymorphism (SNP) in the NBEA gene (P=2.97 × 10(-8), OR: 1.82, 95% CI: 1.47-2.25), although this was not replicated in a smaller sample of 289 migraine cases.Our study is based on self-reported migraine.NBEA encodes neurobeachin, a scaffolding protein primarily expressed in the brain and involved in trafficking of vesicles containing neurotransmitter receptors. This locus has not previously been implicated in migraine per se. We found no evidence of association in data from the GWAS migraine meta-analysis consortium (n=118,710 participants) suggesting that the association might be specific to migraine co-morbid with bipolar disorder.
Christian Kubisch, Lydia Quaye, Frances M. K. Williams, Lynn Cherkas, Markku Koiranen, Anna‐Liisa Hartikainen, Anneli Pouta, Paul M Ridker, M. Arfan Ikram, Kaya K. Jacobsen, Caroline M. Nievergelt, Tetyana Zayats, Tiffany A. Greenwood, Verneri Anttila, Hagop S. Akiskal, Jan Haavik, Ole Bernt Fasmer, John R. Kelsoe, Stefan Johansson, Ketil J. Øedegaard, John R. Kelsoe, Tiffany A. Greenwood, Caroline M. Nievergelt, Rebecca McKinney, Paul D. Shilling, Erin N. Smith, Nicholas J. Schork, Cinnamon S. Bloss, John I. Nürnberger, Howard J. Edenberg, Tatiana Foroud, Daniel L. Koller, Elliot S. Gershon, Judith A. Badner, Chunyu Liu, William A. Scheftner, William Lawson, Evaristus Nwulia, Maria Hipolito, James B. Potash, William Coryell, John Rice, William Byerley, Francis J. McMahon, Wade H. Berrettini, Peter P. Zandi, Pamela B. Mahon, Melvin G. McInnis, Sebastian Zöllner, Peng Zhang, David W. Craig, Szabolics Szelinger, Thomas B. Barrett, Thomas G Schulze, Juho Wedenoja, Mari Kaunisto, Kauko Heikkilä, Jaakko Kaprio, Maija Wessman, Mikko Kallela, Martti Färkkilâ, Ville Artto, Arpo Aromaa, Johan G. Eriksson, Bendik S. Winsvold, John‐Anker Zwart, Padhraig Gormley, Aarno Palotie, Tobias Kurth, Lynda Rose, Julie E. Buring, Paul M. Ridker, Daniel I. Chasman, Francesco Bettella, Stacy Steinberg, Hreinn Stefánsson, Kāri Stefánsson, George McMahon, George Davey Smith, Rainer Malik, Tobias Freilinger, Heinz Erich Wichmann, Martin Dichgans, Bertram Müller−Myhsok, Thomas Meitinger, Boukje de Vries, Gisela M. Terwindt, Anine H Stam, Rune R. Frants, Nadine Pelzer, Claudia M Weller, Ronald Zielman, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg, Sarah E. Medland, Grant W. Montgomery, Nicholas G. Martin, Dale R. Nyholt, Unda Todt, Guntram Borck (2014). Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder. , 172, DOI: https://doi.org/10.1016/j.jad.2014.10.004.
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Type
Article
Year
2014
Authors
100
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1016/j.jad.2014.10.004
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