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  5. Genetically determined body mass index is associated with diffuse large B‐cell lymphoma in polygenic and Mendelian randomization analyses

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Article
en
2025

Genetically determined body mass index is associated with diffuse large B‐cell lymphoma in polygenic and Mendelian randomization analyses

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0 Files

en
2025
Vol 158 (1)
Vol. 158
DOI: 10.1002/ijc.70039

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Elio Riboli
Elio Riboli

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Tongzhang Zheng
Stephen J. Chanock
Nathaniel Rothman
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Abstract

Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05-1.33, p = .005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (ORper SD = 1.12, 95% CI: 1.02-1.23, p = .03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL.

How to cite this publication

Tongzhang Zheng, Stephen J. Chanock, Nathaniel Rothman, Brenda M. Birmann, James R. Cerhan, Sonja I. Berndt, Amy Moore, Eleanor Kane, Lauren R. Teras, Mitchell J. Machiela, Joshua Arias, Orestis A. Panagiotou, Alain Monnereau, Nicole Wong Doo, Zhaoming Wang, Susan L. Slager, Roel Vermeulen, Claire M. Vajdic, Karin E. Smedby, John J. Spinelli, Joseph Vijai, Graham G. Giles, Brian K. Link, Alan A. Arslan, Alexandra Nieters, Paige M. Bracci, Nicola J. Camp, Gilles Salles, Wendy Cozen, Henrik Hjalgrim, Immaculata De Vivo, Hans‐Olov Adami, Demetrius Albanes, Nikolaus Becker, Yolanda Benavente, Simonetta Bisanzi, Paolo Boffetta, Paul E. Brennan, Angela Brooks‐Wilson, Federico Canzian, Jacqueline Clavel, Lucía Conde, David G. Cox, Karen Curtin, Lenka Foretová, Hervé Ghesquières, Bengt Glimelius, Thomas M. Habermann, Jonathan N. Hofmann, Qing Lan, Mark Liebow, Anne Lincoln, Marc Maynadié, James McKay, Mads Melbye, Lucia Miligi, Roger L. Milne, Thierry Jo Molina, Lindsay M. Morton, Kari E. North, Kenneth Offit, Marina Padoan, Sara Piro, Alpa V. Patel, Mark P. Purdue, Vignesh Ravichandran, Elio Riboli, Richard K. Severson, Melissa C. Southey, Anthony Staines, Lesley F. Tinker, Ruth C. Travis, Sophia Wang, Elisabete Weiderpass, Stephanie J. Weinstein (2025). Genetically determined body mass index is associated with diffuse large B‐cell lymphoma in polygenic and Mendelian randomization analyses. , 158(1), DOI: https://doi.org/10.1002/ijc.70039.

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Publication Details

Type

Article

Year

2025

Authors

75

Datasets

0

Total Files

0

Language

en

DOI

https://doi.org/10.1002/ijc.70039

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