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Get Free AccessBackground: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). Results: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. Conclusions: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.
Natalie R. van Zuydam, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan Fernández‐Tajes, Nigel W. Rayner, Neil R. Robertson, Anubha Mahajan, Efthymia Vlachopoulou, Anuj Goel, Marcus E. Kleber, Christopher P. Nelson, Lydia Coulter Kwee, Tõnu Esko, Evelin Mihailov, Reedik Mägi, Lili Milani, Krista Fischer, Stavroula Kanoni, Jitender Kumar, Ci Song, Jaana Hartiala, Nancy L. Pedersen, Markus Perola, Christian Gieger, Annette Peters, Liming Qu, Sara M. Willems, Alex S. F. Doney, Andrew D. Morris, Yan Zheng, Giorgio Sesti, Frank B Hu, Lu Qi, Markku Laakso, Unnur Þorsteinsdóttir, Harald Grallert, Cornelia M. van Duijn, Muredach P. Reilly, Erik Ingelsson, Panos Deloukas, Sek Kathiresan, Andres Metspalu, Svati H. Shah, Juha Sinisalo, Veikko Salomaa, Anders Hamsten, Nilesh J. Samani, Winfried März, Stanley L. Hazen, Hugh Watkins, Danish Saleheen, Andrew P. Morris, Helen M. Colhoun, Leif Groop, Mark I. McCarthy, John Danesh, Jeanette Erdmann, Dongfeng Gu, Jaspal S. Kooner, Robert Roberts, Heribert Schunkert, Themistocles L. Assimes, Stefan Blankenberg, Bernhard O. Boehm, John C. Chambers, Robert Clarke, Rory Collins, George Dedoussis, Paul W. Franks, G. Kees Hovingh, Bong-Jo Kim, Terho Lehtimäki, Ruth McPherson, Markku S. Nieminen, Christopher O’Donnell, Samuli Ripatti, Manjinder S. Sandhu, Stefan Schreiber, Agneta Siegbahn, Cristen J. Willer, Pierre Zalloua, Mark Michael, Timo Kanninen, Barbara Thorand, Giuseppe Remuzzi, David B. Dunger, Angela C. Shore, Ulf Smith, Per-Henrik Groop, Seppo Ylä‐Herttuala, Claudio Cobelli, Riccardo Bellazzi, Ele Ferrannini, Carlo Patrono, Pirjo Nuutila, Paul McKeague, Birgit Steckel-Hamann, Li‐Ming Gan (2020). Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus. , 13(6), DOI: https://doi.org/10.1161/circgen.119.002769.
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Type
Article
Year
2020
Authors
99
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1161/circgen.119.002769
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