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Get Free AccessThe timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (cases = 18,797, controls = 260,246) revealed 6 associated loci, and large genetic similarities with gestational duration. Analysis of the parental transmitted and non-transmitted alleles (n = 136,833) shows that 15 of the gestational duration genetic variants act through the maternal genome, while seven act both through the maternal and fetal, and two act only via the fetal genome. Finally, the maternal effects on gestational duration show signs of antagonistic pleiotropy with the fetal effects on birth weight: maternal alleles that increase gestational duration have negative fetal effects on birth weight.
Pol Solé-Navais, Christopher Flatley, Valgerður Steinthórsdóttir, Marc Vaudel, Julius Juodakis, Jing Chen, Triin Laisk, Abigail L. LaBella, David Westergaard, Jonas Bacelis, Ben Brumpton, Line Skotte, Maria Carolina Borges, Øyvind Helgeland, Anubha Mahajan, Matthias Wielscher, Frederick T. J. Lin, Catherine Briggs, Carol A. Wang, Gunn-Helen Moen, Robin N. Beaumont, Jonathan P. Bradfield, Abin Abraham, Guðmar Þorleifsson, Maiken E. Gabrielsen, Sisse Rye Ostrowski, Dominika Modzelewska, Ellen A. Nøhr, Elina Hyppönen, Amit Srivastava, Octavious Talbot, Catherine Allard, Scott M. Williams, Ramkumar Menon, Beverley M. Shields, Garðar Sveinbjörnsson, Huan Xu, Mads Melbye, Lowe Jr William, Luigi Bouchard, Emily Oken, Ole Birger Pedersen, Daníel F. Guðbjartsson, Christian Erikstrup, Erik Sørensen, Rolv T. Lie, Kari Teramo, Mikko Hallman, Thorhildur Juliusdottir, Hákon Hákonarson, Henrik Ullum, Andrew T. Hattersley, Line Sletner, Mario Merialdi, Sheryl L. Rifas‐Shiman, Þóra Steingrímsdóttir, Denise Scholtens, Christine Power, Jane West, Mette Nyegaard, John A Capra, Anne Heidi Skogholt, Per Magnus, Ole A. Andreassen, Unnur Þorsteinsdóttir, Struan F.A. Grant, Elisabeth Qvigstad, Craig E. Pennell, Marie‐France Hivert, M. Geoffrey Hayes, Paul M Ridker, Mark I. McCarthy, Debbie A. Lawlor, Henriette Svarre Nielsen, Reedik Mägi, Antonis Rokas, Kristian Hveem, Hreinn Stefánsson, Bjarke Feenstra, Pål R. Njølstad, Louis J. Muglia, Rachel M. Freathy, Stefan Johanson, Ge Zhang, Bo Jacobsson (2022). Genetic effects on the timing of parturition and links to fetal birth weight. , DOI: https://doi.org/10.1101/2022.05.04.22274624.
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Type
Preprint
Year
2022
Authors
85
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1101/2022.05.04.22274624
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