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Get Free AccessThe relative risk reductions with sacubitril/valsartan were consistent irrespective of NT-proBNP level in HF patients across the range of LVEF. Consequently, the absolute risk reductions were greatest in patients with higher NT-proBNP levels. (PARADIGM-HF [Prospective Comparison of Angiotensin Receptor-Neprilysin Inhibitor with Angiotensin-Converting-Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial]; NCT01035255; and PARAGON-HF [Prospective Comparison of Angiotensin Receptor-Neprilysin Inhibitor with Angiotensin-Receptor Blockers Global Outcomes in HF with Preserved Ejection Fraction]; NCT01920711).
Toru Kondo, Pardeep S. Jhund, Inder S. Anand, Brian Claggett, Akshay S. Desai, Kieran F. Docherty, Carolyn Lam, Martin Lefkowitz, Aldo Maggioni, Felipe A. Martínez, Margaret M. Redfield, Jean L. Rouleau, Dirk Jan van Veldhuisen, Faı̈ez Zannad, Michael R. Zile, Milton Packer, Scott Solomon, John J.V. McMurray (2025). Effects of Sacubitril/Valsartan According to Natriuretic Peptide Levels in Patients Enrolled in PARADIGM-HF and PARAGON-HF. , 13(6), DOI: https://doi.org/10.1016/j.jchf.2024.12.010.
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Type
Article
Year
2025
Authors
18
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1016/j.jchf.2024.12.010
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