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Get Free AccessIschemia-reperfusion injury (IRI) causes significant morbidity in liver transplantation among other medical conditions. IRI following liver transplantation contributes to poor outcomes and early graft loss. Histone/protein deacetylases (HDACs) regulate diverse cellular processes, play a role in mediating tissue responses to IRI, and may represent a novel therapeutic target in preventing IRI in liver transplantation.
Seth J. Concors, Paul T. Hernandez, Ciaran O’Brien, John DePaolo, Douglas R. Murken, David Aufhauser, Zhong Lin Wang, Yan Xiong, Lauren N. Krumeich, Guanghui Ge, Ulf H. Beier, Tricia R. Bhatti, Alan P. Kozikowski, Leandro A. Alves Avelar, Thomas Kurz, Wayne W. Hancock, Matthew H. Levine (2024). Differential Effects of HDAC6 Inhibition Versus Knockout During Hepatic Ischemia–reperfusion Injury Highlight Importance of HDAC6 C-terminal Zinc-finger Ubiquitin-binding Domain. , 108(10), DOI: https://doi.org/10.1097/tp.0000000000005042.
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Type
Article
Year
2024
Authors
17
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1097/tp.0000000000005042
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