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Get Free AccessMany products of lipid oxidation have been associated with human diseases. These include F2 -isoprostanes (F2-IsoPs), hydroxyeicosatetraenoic acid products (HETEs), and cholesterol oxidation products (COPs). Here we present measurements of F2-IsoPs, HETEs, COPs, and arachidonate in single plasma samples of patients with acute (dengue fever and ischemic stroke) and chronic (Parkinson's) diseases, and in age-matched study controls. Urine samples were collected for F2-IsoPs analysis. Our analysis demonstrated elevated F2-IsoPs levels in ischemic stroke, HETEs in Parkinson's disease, dengue fever, and ischemic stroke, and COPs in Parkinson's disease and dengue fever patients, as compared with those in age-matched study controls. Strong but complex correlations were observed between levels of certain oxidized lipid products and age. The relations between various oxidized lipids and dengue fever, stroke, and Parkinson's disease are discussed in relation to the selection and application of biomarkers of oxidative lipid damage, in particular the need for corrections for age and lipid levels.
Jetty Chung‐Yung Lee, Raymond C.S. Seet, Shan Huang, Lee Hua Long, Barry Halliwell (2008). Different Patterns of Oxidized Lipid Products in Plasma and Urine of Dengue Fever, Stroke, and Parkinson's Disease Patients: Cautions in the Use of Biomarkers of Oxidative Stress. Antioxidants and Redox Signaling, 11(3), pp. 407-420, DOI: 10.1089/ars.2008.2179.
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Type
Article
Year
2008
Authors
5
Datasets
0
Total Files
0
Language
English
Journal
Antioxidants and Redox Signaling
DOI
10.1089/ars.2008.2179
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