Detection of L-Aspartic Acid with Ag-Doped ZnO Nanosheets Using Differential Pulse Voltammetry

Here, a sensitive voltametric electrochemical sensor probe was fabricated to reliably trace the detection of L-aspartic acid in phosphate-buffered medium using a glassy carbon electrode (GCE) layered with a film of wet-chemically prepared Ag₂O-doped ZnO nanosheets (NSs). EDS, FESEM, XPS, and X-ray diffraction analyses were implemented as characterizing tools of prepared NSs to confirm the structural and compositional morphology, binding energies of existing atoms, and the crystallinity of synthesized NSs. The differential pulse voltammetry (DPV) was applied to the trace detection of L-aspartic acid, and exhibited a wide detection range of 15.0~105.0 µM, a limit of detection (3.5 ± 0.15 µM), and good sensitivity (0.2689 µA µM^-1 cm^-2). Besides these the precious reproducibility, stability, and efficient responses were perceived from the voltametric analysis of aspartic acid. Moreover, the proposed aspartic acid was subjected to experiments to potentially detect aspartic acid in real biological samples. Therefore, the development of an enzyme-free sensor by applying this method will be a smart technical approach in the near future.