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Get Free AccessGiven the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
Ana Lleò, Ana Teles, Anders Benjamin Kildal, Andrea Biondi, Andrea Caballero-Garralda, Andrea Ganna, Frauke Degenhardt, David Ellinghaus, Simonas Juzėnas, Jon Lerga-Jaso, Mareike Wendorff, Douglas Maya‐Miles, Florian Uellendahl-Werth, Hesham ElAbd, Malte Rühlemann, Jatin Arora, Onur Özer, Ole Bernt Lenning, Ronny Myhre, May Sissel Vadla, Eike Matthias Wacker, Lars Wienbrandt, Aaron Blandino Ortíz, Adolfo de Salazar, Adolfo Garrido Chercoles, Adriana Palom, Agustı́n Ruiz, Alba-Estela Garcia-Fernandez, Albert Blanco‐Grau, Alberto Mantovani, Alberto Zanella, Aleksander Rygh Holten, Alena Mayer, Alessandra Bandera, Alessandro Cherubini, Alessandro Protti, Alessio Aghemo, Alessio Gerussi, Alfredo Ramı́rez, Alice Braun, Almut Nebel, Ana Barreira, Andrea Gori, Andreas Glück, Andreas Lind, Anja Tanck, Anke Hinney, Anna Carreras, Anna Ludovica Fracanzani, Anna Peschuck, Annalisa Cavallero, Anne Ma Dyrhol‐Riise, Antonella Ruello, Antonio Julià, Antonio Muscatello, Antonio Artigas, Antonio Voza, Ariadna Rando‐Segura, Aurora Solier, Axel Schmidt, Beatriz Cortés, Beatriz Muñoz, Beatriz Nafría-Jiménez, Benedikt Schaefer, Björn‐Erik Ole Jensen, Carla Bellinghausen, Carlo Maj, Carlos Ferrando, Carmen de la Horra, Carmen Quereda, Carsten Skurk, Charlotte Thibeault, Chiara Scollo, Christian Herr, Christoph D. Spinner, Christoph Gassner, Christoph Lange, Cinzia Hu, Cinzia Paccapelo, Clara Lehmann, Claudio Angelini, Claudio Cappadona, Clinton Azuure, Cristiana Bianco, Cristina Cea, Cristina Sancho, Dag Arne Lihaug Hoff, Daniela Galimberti, Daniele Prati, David Haschka, David Jiménez, David Pestaña, David Toapanta, Eduardo Muñiz‐Díaz, Elena Azzolini, Elena Sandoval, Eleonora Binatti, Elio Scarpini, Elisa T. Helbig (2022). Detailed stratified GWAS analysis for severe COVID-19 in four European populations. , 31(23), DOI: https://doi.org/10.1093/hmg/ddac158.
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Type
Article
Year
2022
Authors
99
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1093/hmg/ddac158
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