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Get Free AccessThe ability of a polymer to reptate through a nanopore has an influence on its circulatory half-life and biodistribution, since many physiological barriers contain nanopores. A cyclic polymer lacks chain ends, and therefore, cyclic polymers with molecular weights greater than the renal threshold for elimination should circulate longer than their linear-polymer counterparts when injected into animals. As predicted, radiolabeled cyclic polymers with molecular weights greater than the renal threshold have longer blood circulation times in mice than do linear polymers of comparable molecular weight.
Bo Chen, Nichole Macaraeg, Megan E. Fox, Jean Mj Frechet, Francis C. Szoka, Norased Nasongkla (2009). Dependence of Pharmacokinetics and Biodistribution on Polymer Architecture: Effect of Cyclic versus Linear Polymers. , 131(11), DOI: https://doi.org/10.1021/ja900062u.
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Type
Article
Year
2009
Authors
6
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1021/ja900062u
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