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Get Free AccessHypoxia inducible factor (HIF)-1 plays an important role in cellular adaptation to hypoxia by activating oxygen-regulated genes such as vascular endothelial growth factor (VEGF) and erythropoietin. Sputum VEGF levels are reported to be decreased in COPD, despite hypoxia. Here we show that patients with COPD fail to induce HIF-1α and VEGF under hypoxic condition because of a reduction in histone deacetylase (HDAC) 7.
Masako To, Satoshi Yamamura, Kenichi Akashi, Catherine E. Charron, Kosuke Haruki, Peter J Barnes, Kazuhiro Ito (2011). Defect of Adaptation to Hypoxia in Patients With COPD Due to Reduction of Histone Deacetylase 7. , 141(5), DOI: https://doi.org/10.1378/chest.11-1536.
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Type
Article
Year
2011
Authors
7
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1378/chest.11-1536
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