0 Datasets
0 Files
Get instant academic access to this publication’s datasets.
Yes. After verification, you can browse and download datasets at no cost. Some premium assets may require author approval.
Files are stored on encrypted storage. Access is restricted to verified users and all downloads are logged.
Yes, message the author after sign-up to request supplementary files or replication code.
Join 50,000+ researchers worldwide. Get instant access to peer-reviewed datasets, advanced analytics, and global collaboration tools.
✓ Immediate verification • ✓ Free institutional access • ✓ Global collaborationJoin our academic network to download verified datasets and collaborate with researchers worldwide.
Get Free AccessBackgrounds: Multiple polymorphisms affecting smoking behavior have been identified through genome-wide association studies. Circulating levels of the nicotine metabolite cotinine is a marker of recent smoking exposure. Hence, genetic variants influencing smoking behavior are expected to be associated with cotinine levels.
Methods: We conducted an analysis in a lung cancer case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We investigated the effects of single-nucleotide polymorphisms (SNP) previously associated with smoking behavior on (i) circulating cotinine and (ii) lung cancer risk. A total of 894 cases and 1,805 controls were analyzed for cotinine and genotyped for 10 polymorphisms on 7p14, 8p11, 10q23, 15q25, and 19q13.
Results: Two variants in the nicotinic acetylcholine receptor subunit genes CHRNA5 and CHRNA3 on 15q25, rs16969968 and rs578776, were associated with cotinine (P = 0.001 and 0.03, respectively) in current smokers and with lung cancer risk (P < 0.001 and P = 0.001, respectively). Two 19q13 variants, rs7937 and rs4105144, were associated with increased cotinine (P = 0.003 and P < 0.001, respectively) but decreased lung cancer risk (P = 0.01 for both, after adjusting for cotinine). Variants in 7p14, 8p11, and 10q23 were not associated with cotinine or lung cancer risk.
Conclusions: 15q25 and 19q13 SNPs were associated with circulating cotinine. The directions of association for 15q25 variants with cotinine were in accordance with that expected of lung cancer risk, whereas SNPs on 19q13 displayed contrasting associations of cotinine and lung cancer that require further investigation.
Impact: This study is the largest to date investigating the effects of polymorphisms affecting smoking behavior on lung cancer risk using circulating cotinine measures as proxies for recent smoking behavior. Cancer Epidemiol Biomarkers Prev; 20(10); 2250–61. ©2011 AACR.
Maria Timofeeva, James McKay, George Davey Smith, Mattias Johansson, Graham Byrnes, Amélie Chabrier, Caroline L. Relton, Per Magne Ueland, Dan Joseph Stein, Øivind Midttun, Ottar Nygård, Nadia Slimani, Isabelle Romieu, Françoise Clavel-Chapelon, Marie‐Christine Boutron‐Ruault, Guy Fagherazzi, Rudolf Kaaks, Birgit Teucher, Heiner Boeing, Cornelia Weikert, H. Bas Bueno-de-Mesquita, Carla H. van Gils, Petra H. Peeters, Antonio Agudo, Aurelio Barricarte, José María Huerta, Laudina Rodríguez, María‐José Sánchez, Nerea Larrañaga, Kay‐Tee Khaw, Nicholas J. Wareham, Naomi E. Allen, Ruth C. Travis, V. Gallo, Teresa Norat, Vittorio Krogh, Giovanna Masala, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Antonia Trichopoulou, Παγώνα Λάγιου, Dimitrios Trichopoulos, Torgny Rasmuson, Göran Hallmans, Elio Ríboli, Paolo Vineis, Paul Brennan (2023). Data from Genetic Polymorphisms in 15q25 and 19q13 Loci, Cotinine Levels, and Risk of Lung Cancer in EPIC. , DOI: https://doi.org/10.1158/1055-9965.c.6514824.v1.
Datasets shared by verified academics with rich metadata and previews.
Authors choose access levels; downloads are logged for transparency.
Students and faculty get instant access after verification.
Type
Preprint
Year
2023
Authors
48
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1158/1055-9965.c.6514824.v1
Access datasets from 50,000+ researchers worldwide with institutional verification.
Get Free Access
