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Get Free AccessTriple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. Cancer Res; 71(19); 6240–9. ©2011 AACR.
Kristen N. Stevens, Celine M. Vachon, Adam M. Lee, Susan L. Slager, Timothy G. Lesnick, Curtis Olswold, Peter A. Fasching, Penelope Miron, Diana Eccles, Jane Carpenter, Andrew K. Godwin, Christine B. Ambrosone, Robert Winqvist, Hiltrud Brauch, Marjanka K. Schmidt, Angela Cox, Simon S. Cross, Elinor J. Sawyer, Arndt Hartmann, Matthias W. Beckmann, Rüdiger Schulz-Wendtland, Arif B. Ekici, William Tapper, Susan M. Gerty, Lorraine Durcan, Nikki Graham, Rebecca Hein, Stephan Nickels, Dieter Flesch‐Janys, Judith Heinz, Hans‐Peter Sinn, Irene Konstantopoulou, Florentia Fostira, Dimitrios Pectasides, Meletios A Dimopoulos, George Fountzilas, Christine L. Clarke, Rosemary L. Balleine, Janet E. Olson, Zachary Fredericksen, Robert B. Diasio, Harsh B. Pathak, Eric A. Ross, JoEllen Weaver, Thomas Rüdiger, Asta Försti, Thomas Dünnebier, Foluso O. Ademuyiwa, Swati Kulkarni, Katri Pylkäs, Arja Jukkola‐Vuorinen, Yon‐Dschun Ko, Erik Van Limbergen, Hilde Janssen, Julian Peto, Olivia Fletcher, Graham G. Giles, Laura Baglietto, Senno Verhoef, Ian Tomlinson, Veli‐Matti Kosma, Jonathan Beesley, Dario Greco, Carl Blomqvist, Astrid Irwanto, Jianjun Liu, Fiona M. Blows, Sarah‐Jane Dawson, Sara Margolin, Nicholas G. Martin, Grant W. Montgomery, Diether Lambrechts, Isabel dos‐Santos‐Silva, Gianluca Severi, Ute Hamann, Paul D.P. Pharoah, Douglas F. Easton, Jenny Chang‐Claude, Drakoulis Yannoukakos, Heli Nevanlinna, Xianshu Wang, Fergus J. Couch (2023). Data from Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer. , DOI: https://doi.org/10.1158/0008-5472.c.6502184.
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Type
Preprint
Year
2023
Authors
82
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1158/0008-5472.c.6502184
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