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Get Free AccessWe report the crystal structures of two inhibitors of Plasmodium falciparum macrophage migration inhibitory factor (PfMIF) with nanomolar Ki's, analyze their interactions with the active site of PfMIF, and provide explanations regarding their selectivity of PfMIF versus human MIF. These inhibitors were also found to selectively inhibit interactions between PfMIF and the human MIF receptor CD74. The results of this study provide the framework for the development of new therapeutics that target PfMIF.
Georgios Pantouris, Deepa Rajasekaran, Alvaro Baeza Garcia, Victor G. Ruiz, Lin Leng, William L. Jorgensen, Richard Bucala, Elias Lolis (2014). Crystallographic and Receptor Binding Characterization of <i>Plasmodium falciparum</i> Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors. Journal of Medicinal Chemistry, 57(20), pp. 8652-8656, DOI: 10.1021/jm501168q.
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Type
Article
Year
2014
Authors
8
Datasets
0
Total Files
0
Language
English
Journal
Journal of Medicinal Chemistry
DOI
10.1021/jm501168q
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