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Get Free AccessAbstract Background Maternal congenital heart disease (CHD) is the most common cardiac condition to complicate pregnancy and women now become pregnant even with complex CHD. The Registry Of Pregnancy And Cardiac disease (ROPAC) examines the relationship between maternal heart disease and pregnancy outcome. Methods The ESC EORP ROPAC is a worldwide prospective registry of pregnancies in women with structural heart disease (n=5739, recruiting between 2007-2018), including CHD. Maternal and fetal outcomes were examined in all women with CHD. Multivariable regression was used to identify associations with a composite endpoint of maternal mortality and/or heart failure. Results In CHD pregnancies (n=3295, mean age 29 years), maternal mortality was 0.3% and heart failure occurred in 6.6%. Preterm births (16%) and Caesarean section (46.3%) were higher than global averages, but otherwise cardiac, obstetric and fetal outcomes were good. The composite endpoint was highest in complex CHD: Eisenmenger syndrome (58.1%), congenitally corrected transposition of the great arteries (12.8%), Fontan circulation (11.2%), double outlet right ventricle (11.1%). Pre-pregnancy signs of heart failure (OR 10.6, 95% CI 7.1-16), multiple gestation (4.6, 2-10.8), pulmonary hypertension (2.5, 1.5-4), estimated LVEF Conclusion Overall pregnancy outcomes for women with CHD are good but women with complex CHD are at increased risk of complications. Pre-pregnancy assessment can identify women at increased risk of an adverse outcome and should be used to counsel women appropriately.
Karishma P. Ramlakhan, Mark R. Johnson, Małgorzata Lelonek, Aly M A Saad, Zaur Gasimov, Н. В. Шарашкина, Patrick Thornton, Margaret Arstall, Roger Hall, Roger Hall, Jolien W. Roos‐Hesselink, Jolien W. Roos‐Hesselink, Joerg I. Stein, William Parsonage, Werner Budts, Julie De Backer, Jasmin Grewal, Ariane Marelli, Harald Kaemmerer, Guillaume Jondeau, Mark R. Johnson, Aldo Maggioni, Luigi Tavazzi, Ulf Thilén, Uri Elkayam, Catherine M Otto, Karen Sliwa, Analía Aquieri, Hilda Ruda Vega, Javier Hojman, J. Caparrós, Manuel Vázquez Blanco, Margaret Arstall, Chang‐Min Chung, Gnanadevan Mahadavan, Emily Aldridge, M. Wittwer, Y.Y. Chow, William Parsonage, Karin Lust, N. Collins, Gillian Robinson- Warner, Rachael Hatton, Adrienne Gordon, Elin Nyman, Joerg I. Stein, E. Donhauser, H Gabriel, A. Bahshaliyev, Faiq Guliyev, I. Hasanova, T. Jahangirov, Zaur Gasimov, Abu Salim, C M Ahmed, Firoza Begum, M.H. Hoque, Manzoor Mahmood, M N Islam, P. P. Haque, Sudipto Banerjee, Tahira Parveen, Marielle Morissens, Julie De Backer, Laurent Demulier, Michèle de Hosson, Werner Budts, M. Beckx, Mate Kozić, Mila Lovrić, Tamara Kovačević-Preradović, Nataliya Chilingirova, Pencho Kratunkov, Noor Alaudin Abdul Wahab, Sara McLean, Elaine Gordon, Laura Otto Walter, Ariane Marelli, A. R. Montesclaros, Germán Monsalve, Ciro Rodríguez, F. Balthazar, V. Quintero, W. Palacio, L. A. Mejía Cadavid, Edison Muñoz-Ortiz, F. Fortich Hoyos, E Guerrero, João Ricardo, J. Velasquez Penagos, Zdeněk Vavera, Jana Popelová, Niels Vejlstrup, Lene Grønbeck, M. Johansen, AS Ersbøll (2021). Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC). , 3, DOI: https://doi.org/10.1016/j.ijcchd.2021.100107.
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Type
Article
Year
2021
Authors
96
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1016/j.ijcchd.2021.100107
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