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Get Free AccessThese findings suggest cladribine was associated with superior effectiveness in reducing disability progression over 25 months, likely due to reduced PIRA, despite comparable short-term NEDA-3 outcomes. However, relapse prevention declined after 36 months, suggesting retreatment or therapy modification within 3 years may be needed to maintain long-term disease control.
Shalom Haggiag, Luca Prosperini, Massimo Filippi, Maria A. Rocca, Pietro Iaffaldano, Francesco Patti, Matilde Inglese, Giovanna Borriello, Rocco Totaro, Giacomo Lus, Roberta Fantozzi, Vincenzo Brescia Morra, Silvia Romano, Jessica Frau, Girolama Alessandra Marfia, Giorgia Teresa Maniscalco, Maria Pia Amato, Alessia Di Sapio, Giovanna De Luca, Sebastiano Giuseppe Crisafulli, Erica Curti, Matteo Foschi, Paola Cavalla, Giuseppe Salemi, Antonella Conte, Paola Valentino, Diana Ferraro, Alessandra Lugaresi, Sabrina Realmuto, Paola Perini, Elisabetta Ferraro, Sara Montepietra, Carlo Avolio, Marika Vianello, Paola Gazzola, Fabiana Marinelli, Livia Pasquali, Sebastiano Bucello, Domizia Vecchio, Alessandra Protti, Francesca Sangalli, Marco Rovaris, Luigi Grimaldi, Milena De Riz, Paolo Barone, Valentina Scarano, Bonaventura Ardito, Leonardo Sinisi, Paolo Immovilli, Ilaria Pesci, Elena Colombo, Marco Capobianco, Cristina Fioretti, Maria Gabriella Coniglio, Antonello Giordano, Tiziana Tassinari, Daniela Cargnelutti, Francesca Matta, Mario Falcini, Maurizia Gatto, Nerina Mascoli, Roberto Balgera, Sessa Edoardo, Rosa Iodice, Claudio Solaro, Katrin Plewnia, Mario Santangelo, Valeria Barcella, Maria Teresa Ferrò, Francesco Sica, Raffaella Cerqua, Giuseppe Santuccio, Francesco Corea, Alessandro Leone, Davide Nasuelli, Augusto Maria Rini, Giampaolo Brichetto, Salvatore Cottone, Monica Ulivelli, Matteo Pizzorno, Patrizia Rossi, Eva Milano, Luigi Zuliani, Serena Ruggieri, Claudio Gasperini, María Trojano, Carla Tortorella (2025). Comparative Effectiveness of Cladribine and S1P Receptor Modulators in Treatment-Naive Relapsing-Remitting MS. , 8(11), DOI: https://doi.org/10.1001/jamanetworkopen.2025.41025.
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Type
Article
Year
2025
Authors
87
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1001/jamanetworkopen.2025.41025
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