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Get Free AccessConjugate to ameliorate! Polymeric drug delivery using a synthetic tubulysin analogue in C26 tumor bearing mice is described. A single dose of this conjugate (shown) resulted in a 90 % increase in the average lifespan of the mice as compared to groups given a phosphate-buffered saline control or the free tubulysin analogue. Moreover, 37 % of the mice given the polymeric formulation were tumor free at the conclusion of the study.
William C. Floyd, Gopal K. Datta, Shinichi Imamura, Heidi M. Ferguson, Katherine Jerger, Andrew W. Patterson, Megan E. Fox, Francis C. Szoka, Jean Mj Frechet, Jonathan A. Ellman (2010). Chemotherapeutic Evaluation of a Synthetic Tubulysin Analogue–Dendrimer Conjugate in C26 Tumor Bearing Mice. , 6(1), DOI: https://doi.org/10.1002/cmdc.201000377.
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Type
Article
Year
2010
Authors
10
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1002/cmdc.201000377
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