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Get Free AccessBrain aging did not relate to SPH in the full sample. However, a diagnosis-by-age interaction was observed across analyses, and was strongest in formally diagnosed SPH. Post-hoc analyses showed a subtle advanced brain aging in young adults with formally diagnosed SPH. Taken together, these findings indicate the importance of clinical severity, impairment and persistence, and may suggest a slightly earlier end to maturational processes or subtle decline of brain structure in SPH.
Kimberly V. Blake, Kevin Hilbert, Jonathan Ipser, Laura K. M. Han, Janna Marie Bas‐Hoogendam, Fredrik Åhs, Jochen Bauer, Katja Beesdo‐Baum, Johannes Björkstrand, Laura Blanco‐Hinojo, Joscha Böhnlein, Robin Bülow, Marta Cano, Narcı́s Cardoner, Xavier Caseras, Udo Dannlowski, Mats Fredrikson, Liesbet Goossens, Hans J. Grabe, Dominik Grotegerd, Tim Hahn, Alfons O. Hamm, Ingmar Heinig, Martin J. Herrmann, D. J. Hofmann, Hamidreza Jamalabadi, Andreas Jansen, Merel Kindt, Tilo Kircher, Anna Luisa Klahn, Katja Koelkebeck, Axel Krug, Elisabeth J. Leehr, Martín Lotze, Jürgen Margraf, Markus Muehlhan, Igor Nenadić, Wenceslao Peñate Castro, Andre Pittig, Jens Plag, Jesús Pujol, Jan Richter, Isabelle C. Ridderbusch, Francisco Rivero, Axel Schäfer, Judith Schäfer, Anne Schienle, Elisabeth Schrammen, Koen Schruers, Esther Seidl, Rudolf Stark, Benjamin Straube, Thomas Straube, Andreas Ströhle, Lea Teutenberg, Sophia I. Thomopoulos, Carlos Ventura‐Bort, Renée M. Visser, Henry Völzke, Albert Wabnegger, Julia Wendt, Hans‐Ulrich Wïttchen, Katharina Wittfeld, Yunbo Yang, Anna Zilverstand, Peter Zwanzger, Lianne Schmaal, Moji Aghajani, Daniel S. Pine, Paul M. Thompson, Nic J.A. van der Wee, Dan Joseph Stein, Ulrike Lueken, Nynke A. Groenewold (2025). Brain Aging in Specific Phobia: An ENIGMA-Anxiety Mega-Analysis. , DOI: https://doi.org/10.1101/2025.03.19.25323474.
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Type
Preprint
Year
2025
Authors
74
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1101/2025.03.19.25323474
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