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Get Free AccessAlcohol intake was associated with methylation levels at two CpG sites. Evidence from DMR and FL analyses indicated that dietary folate and alcohol intake may be associated with genomic regions with tumor suppressor activity such as the GSDMD and HOXA5 genes. These results were in line with the hypothesis that epigenetic mechanisms play a role in the association between folate and alcohol, although further studies are warranted to clarify the importance of these mechanisms in cancer.
Flavie Perrier, V. Viallon, Srikant Ambatipudi, Akram Ghantous, Cyrille Cuenin, Héctor Hernández‐Vargas, Véronique Chajès, Laura Baglietto, Marco Matejcic, Hortensia Moreno-Macías, Tilman Kühn, H. Boeing, Anna Karakatsani, Αnastasia Kotanidou, Antonia Trichopoulou, Sabina Sieri, Salvatore Panico, Francesca Fasanelli, Michael Dölle, N. Charlotte Onland‐Moret, Ivonne Sluijs, Elisabete Weiderpass, J. Ramón Quirós, Antonio Agudo, José María Huerta, Eva Ardanáz, M. Dorronsoro, Tammy Y. N. Tong, Konstantinos K. Tsilidis, Elio Riboli, Marc J. Gunter, Z. Herceg, Pietro Ferrari, Isabelle Romieu (2019). Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study. , 11(1), DOI: https://doi.org/10.1186/s13148-019-0637-x.
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Type
Article
Year
2019
Authors
34
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1186/s13148-019-0637-x
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