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Get Free AccessThe detection of antinuclear autoantibody (ANA) is dependent on many factors and varies between the populations. The aim of the study was first to assess the prevalence of ANA in the Polish adult population depending on age, sex and the cutoff threshold used for the results obtained. Second, we estimated the occurrence of individual types of ANA-staining patterns. We tested 1731 patient samples using commercially available IIFA using two cutoff thresholds of 1:100 and 1:160. We found ANA in 260 participants (15.0%), but the percentage of positive results strongly depended on the cutoff level. For a cutoff threshold 1:100, the positive population was 19.5% and for the 1:160 cutoff threshold, it was 11.7%. The most prevalent ANA-staining pattern was AC-2 Dense Fine speckled (50%), followed by AC-21 Reticular/AMA (14.38%) ANA more common in women (72%); 64% of ANA-positive patients were over 50 years of age. ANA prevalence in the Polish population is at a level observed in other highly developed countries and is more prevalent in women and elderly individuals. To reduce the number of positive results released, we suggest that Polish laboratories should set 1:160 as the cutoff threshold.
Paweł Krzemień, Sławomir Kasperczyk, Maciej Banach, Aleksandra Kasperczyk, Michał Dobrakowski, Tomasz Tomasik, Adam Windak, Mirosław Mastej, Alberico L. Catapano, Kausik K. Ray, Dimitri P. Mikhailidis, Peter P. Tóth, George Howard, Professor Gregory Lip, Maciej Tomaszewski, Fadi J. Charchar, Naveed Sattar, Bryan Williams, Thomas M. MacDonald, Peter E. Penson, Jacek Jerzy Jozwiak, B. Al-Shaer, W. Andrusewicz, M. Andrzejczuk-Rosa, E. Anusz-Gaszewska, Anna Baginska, P. Balawajder, Gaurav Banka, E. Barańska-Skubisz, B. Barbara Przyczyna, S. Bartkowiak, J. Bartodziej, Małgorzata Bartosiewicz, M. Basałyga, A. Batyra, Aneta Bąk, Mark S. Bednarz, K. Bejnar, W. Bernacki, M. Betiuk-Kwiatkowska, S. Biegaj, Marta Bień, W. Bilski, M. Biłogan, G. Biruta-Pawłowska, A. Biskup, Barbara Błaszczyk, H. Błaszczyk, T. Błońska-Jankowska, B. Bogacka-Gancarczyk, Marzena Bojanowska, Elżbieta Bonda-Ostaszewska, J. Borowik-Skwarek, J. Borowska, James V. Bruckner, Jerzy Brzostek, M. Brzuchacz, M. Budzyńska, I. Bulzacka-Fugiel, J. Bulzak, K. Bunikowski, A. Cebulska, T. Celka, E. Cempel-Nowak, W. Chechliński, A. Chludzińska, D. Chmiel, Magdalena Chmielewska, M. Cichy, A. Ciemięga, A. Ciepluch, I. Cieszyńska, Beata Czajka, B. Czapla, M. Czerner, Barbara Czerwińska, W. Czuryszkiewicz, E. Daleka, Z. Dawid, Magdalena Dąbrowska, Renata Dąbrowska, D. Dąbrowski, Maciej Dąbrowski, K. Demczyszyn, A. Dębowska-Serwińska, Jacek Dmochowski, J. Dobrzecka-Kiwior, E. Dolanowska, H. Dolanowski, P. Dołek, Michał Domagała, Henryk A. Domanski, A. Doszel, D. Duda, Magdalena Dudkowska, B. Dudziuk, P. Dybciak, M. Dymanowski, L. Dziadzio-Bolek (2021). Analysis of the impact of sex and age on the variation in the prevalence of antinuclear autoantibodies in Polish population: a nationwide observational, cross-sectional study. , 42(2), DOI: https://doi.org/10.1007/s00296-021-05033-9.
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Type
Article
Year
2021
Authors
99
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1007/s00296-021-05033-9
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