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Get Free AccessAbstract A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed, which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3,049 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1,446 individuals with PTSD and 1,603 controls (2152 males/897 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen’s d =−0.12, p =0.0021). The tapetum connects the left and right hippocampus, structures for which structure and function have been consistently implicated in PTSD. Results remained significant/similar after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.
Emily L. Dennis, Seth G. Disner, Negar Fani, Lauren E. Salminen, Mark W. Logue, Emily K. Clarke‐Rubright, Courtney C. Haswell, Christopher L. Averill, Lee A. Baugh, Jessica Bomyea, Steven E. Bruce, Jiook Cha, Kyle Choi, Nicholas D. Davenport, Maria Densmore, Stefan S. du Plessis, Gina L. Forster, Jessie L. Frijling, A. Gönenç, Staci A. Gruber, Daniel W. Grupe, Jeffrey P. Guenette, Jasmeet P. Hayes, David Hofmann, Jonathan Ipser, Tanja Jovanović, Sinéad Kelly, Mitzy Kennis, Philipp Kinzel, Saskia B.J. Koch, Inga K. Koerte, Sheri‐Michelle Koopowitz, Mayuresh S. Korgaonkar, John H. Krystal, Lauren A. M. Lebois, Gen Li, Vincent A. Magnotta, Antje Manthey, Geoffrey May, Deleene S. Menefee, Laura Nawijn, Scott M. Nelson, Richard WJ Neufeld, Jack B. Nitschke, Daniel C.M. O'Doherty, Matthew Peverill, Kerry J. Ressler, Annerine Roos, Margaret A. Sheridan, Anika Sierk, Alan N. Simmons, Raluca M. Simons, Jeffrey S. Simons, Jennifer S. Stevens, Benjamin Suarez‐Jimenez, Danielle R. Sullivan, Jean Théberge, Jana K. Tran, Leigh van den Huevel, Steven J. van der Werff, Sanne J.H. van Rooij, Mirjam van Zuiden, Carmen Vélez, Mieke Verfaellie, Robert Vermeiren, Benjamin Wade, Tor D. Wager, Henrik Walter, Sherry Winternitz, Jonathan D. Wolff, Gerald E. York, Ye Zhu, Xi Zhu, Chadi G. Abdallah, Richard A. Bryant, Judith K. Daniels, Richard J. Davidson, Kelene A. Fercho, Carol E. Franz, Elbert Geuze, Evan M. Gordon, Milissa L. Kaufman, William S. Kremen, Jim Lagopoulos, Ruth A. Lanius, Michael J. Lyons, Stephen R. McCauley, Regina E. McGlinchey, Katie A. McLaughlin, William Milberg, Yuval Neria, Miranda Olff, Soraya Seedat, Martha E. Shenton, Scott R. Sponheim, Dan Joseph Stein, Murray B. Stein, Thomas Straube, David F. Tate, Nic J. van der Wee (2019). Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium. , DOI: https://doi.org/10.1101/677153.
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Type
Preprint
Year
2019
Authors
100
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1101/677153
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