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  5. Alcohol intake and the risk of intracerebral hemorrhage in the elderly

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Article
en
2018

Alcohol intake and the risk of intracerebral hemorrhage in the elderly

0 Datasets

0 Files

en
2018
Vol 91 (3)
Vol. 91
DOI: 10.1212/wnl.0000000000005814

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Giancarlo Agnelli
Giancarlo Agnelli

University Of Perugia

Verified
Paolo Costa
Mario Grassi
Licia Iacoviello
+77 more

Abstract

Objective

To investigate the role of alcohol as a causal factor for intracerebral hemorrhage (ICH) and whether its effects might vary according to the pathogenic mechanisms underlying cerebral bleeding.

Methods

We performed a case-control analysis, comparing a cohort of consecutive white patients with ICH aged 55 years and older with a group of age- and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Haemorrhage in Italy (MUCH-Italy) between 2002 and 2014. Participants were dichotomized into excessive drinkers (>45 g of alcohol) and light to moderate drinkers or nondrinkers. To isolate the unconfounded effect of alcohol on ICH, we used causal directed acyclic graphs and the back-door criterion to select a minimal sufficient adjustment set(s) of variables for multivariable analyses. Analyses were performed on the whole group as well as separately for lobar and deep ICH.

Results

We analyzed 3,173 patients (1,471 lobar ICH and 1,702 deep ICH) and 3,155 controls. After adjusting for the preselected variables in the minimal sufficient adjustments, heavy alcohol intake was associated with deep ICH risk (odds ratio [OR], 1.68; 95% confidence interval [CI], 1.36–2.09) as well as with the overall risk of ICH (OR, 1.38; 95% CI, 1.17–1.63), whereas no effect was found for lobar ICH (OR, 1.01; 95% CI, 0.77–1.32).

Conclusions

In white people aged 55 years and older, high alcohol intake might exert a causal effect on ICH, with a prominent role in the vascular pathologies underlying deep ICH.

How to cite this publication

Paolo Costa, Mario Grassi, Licia Iacoviello, Marialuisa Zedde, Simona Marcheselli, Giorgio Silvestrelli, Maria Luisa DeLodovici, Maria Sessa, Andrea Zini, Maurizio Paciaroni, Cristiano Azzini, Massimo Gamba, Massimo Del Sette, Antonella Toriello, Claudia Gandolfo, Domenico Marco Bonifati, Rossana Tassi, Anna Cavallini, Alberto Chiti, Rocco Salvatore Calabrò, Francesco Grillo, Paolo Bovi, Giampaolo Tomelleri, Augusto Di Castelnuovo, Marco Ritelli, Giancarlo Agnelli, Alessandro De Vito, Nicola Pugliese, Giuseppe Martini, Corrado Lodigiani, Andrea Morotti, Loris Poli, Valeria De Giuli, Filomena Caria, Claudio Cornali, Giovanni de Gaetano, Marina Colombi, Alessandro Padovani, Alessandro Pezzini, Paolo Costa, Mario Grassi, Licia Iacoviello, Cataldo D’Amore, Monica Acciarresi, Valeria Caso, Andrea Alberti, Michele Venti, Laura Vandelli, Maria Luisa Dell’Acqua, Anna Maria Simone, Paolo Nichelli, Alessia Lanari, Alfonso Ciccone, Elisabetta Del Zotto, Nicola Gilberti, Mauro Magoni, Gabriele Zucco, Davide Massucco, Cinzia Finocchi, Maurizio Balestrino, Monica Carletti, Cecilia Zivelonghi, Carmela Casella, Paolo Spina, Rossella Musolino, Placido Bramanti, Lucia Princiotta Cariddi, Elisa Giorli, Davide Strambo, Giacomo Giacalone, Aurelio Glielmi, Giampiero Volpe, Giuseppe Micieli, Vincenzo Montano, Padroni , Giovanna Marotta, Giovanni Malferrari, Norina Marcello, L Cucurachi, Alessia Giossi (2018). Alcohol intake and the risk of intracerebral hemorrhage in the elderly. , 91(3), DOI: https://doi.org/10.1212/wnl.0000000000005814.

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Publication Details

Type

Article

Year

2018

Authors

80

Datasets

0

Total Files

0

Language

en

DOI

https://doi.org/10.1212/wnl.0000000000005814

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