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Get Free AccessSignificance The thyroid is essential for maintaining systemic homeostasis by regulating thyroid hormone concentrations in the bloodstream. This study describes an organoid-based model system to study mouse and human thyroid biology. Moreover, the study explores the potential of human organoids for modeling autoimmune disease, the anti-TSH receptor (TSHR) antibody-driven Graves’ hyperthyroidism.
Jelte van der Vaart, Lynn Bosmans, Stijn F. Sijbesma, Kèvin Knoops, Willine J. van de Wetering, Henny G. Otten, Harry Begthel, Inne H.M. Borel Rinkes, Jeroen Korving, Eef G.W.M. Lentjes, Carmen López-Iglesias, Peter J. Peters, Hanneke M van Santen, Menno R. Vriens, Hans Clevers, Jelte van der Vaart, Lynn Bosmans, Stijn F. Sijbesma, Kèvin Knoops, Willine J. van de Wetering, Henny G. Otten, Harry Begthel, Inne H.M. Borel Rinkes, Jeroen Korving, Eef G.W.M. Lentjes, Carmen López-Iglesias, Peter J. Peters, Hanneke M van Santen, Menno R. Vriens, Hans Clevers (2021). Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism. , 118(51), DOI: https://doi.org/10.1073/pnas.2117017118.
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Type
Article
Year
2021
Authors
30
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1073/pnas.2117017118
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