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  5. A Scalable Toolkit for Modeling 3D Surface-based Brain Geometry

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Preprint
en
2025

A Scalable Toolkit for Modeling 3D Surface-based Brain Geometry

0 Datasets

0 Files

en
2025
DOI: 10.1101/2025.08.06.668521

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Dan Joseph Stein
Dan Joseph Stein

Institution not specified

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Yanghee Im
Leila Nabulsi
Melody J.Y. Kang
+69 more

Abstract

Abstract 3D surface-based computational mapping is more sensitive to localized brain alterations in neurological, developmental and psychiatric conditions than traditional gross volumetric analysis, providing fine-scale 3D maps of a wide range of surface-based features. Here we introduce a scalable toolkit for large-scale computational surface analysis, with efficient algorithms for multisite data integration, statistical harmonization, accelerated multivariate statistics, and visualization. We showcase the utility of the toolkit by mapping subcortical shape variations and factors that affect them across 21 international samples from the ENIGMA Bipolar Disorder Working Group (N=3,373).

How to cite this publication

Yanghee Im, Leila Nabulsi, Melody J.Y. Kang, Sophia I. Thomopoulos, Ana M. Diaz Zuluaga, Anders M. Dale, Andriana Karuk, Annabella Di Giorgio, Benson Mwangi, Boris A. Gutman, Bronwyn J. Overs, Carlos López‐Jaramillo, Colm McDonald, Dan Joseph Stein, Dara M. Cannon, David C. Glahn, Diego Hidalgo‐Mazzei, Diliana Pecheva, Dominik Grotegerd, Edith Pomarol-Clotet, Eduard Vieta, Émilie Olié, Enric Vilajosana Chertó, Fabio Sambataro, Fleur M. Howells, Freda Scheffler, Geraldo F. Busatto, Gerard Anmella, Giovana Zunta‐Soares, Gloria Roberts, Henk Temmingh, Ian H. Gotlib, Ingrid Agartz, Jair C. Soares, James A. Karantonis, James J. Prisciandaro, Janice M. Fullerton, Joaquim Raduà, Jonathan Savitz, Josselin Houenou, Kang Sim, Kenichiro Harada, Klaus Berger, Koji Matsuo, Lakshmi N. Yatham, Lars T. Westlye, Lisa T. Eyler, Lisa S. Furlong, Anna Luisa Klahn, Marco Hermesdorf, Marcus V. Zanetti, Matthew J. Kempton, Matthew D. Sacchet, Mikael Landén, Mon‐Ju Wu, Pedro G. P. Rosa, Philip B. Mitchell, Pravesh Parekh, Raymond Salvador, Rayus Kuplicki, Salvador Sarró, Susan L. Rossell, Tamsyn E. Van Rheenen, Theodore D. Satterthwaite, Tilo Kircher, Tomáš Hájek, Udo Dannlowski, Xavier Caseras, Yuji Zhao, Ole A. Andreassen, Paul M. Thompson, Christopher R. K. Ching (2025). A Scalable Toolkit for Modeling 3D Surface-based Brain Geometry. , DOI: https://doi.org/10.1101/2025.08.06.668521.

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Publication Details

Type

Preprint

Year

2025

Authors

72

Datasets

0

Total Files

0

Language

en

DOI

https://doi.org/10.1101/2025.08.06.668521

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