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Get Free AccessAbstract Patient-derived tumor xenograft (PDX)/organoid (PDO), driven by cancer stem cells (CSC), are considered the most predictive models for translational oncology. Large PDX collections reflective of patient populations have been created and used extensively to test various investigational therapies, including in population-trials as surrogate subjects in vivo. PDOs are recognized as in vitro surrogates for patients amenable for high-throughput screening (HTS). We have built a biobank of carcinoma PDX-derived organoids (PDXOs) by converting an existing PDX library and confirmed high degree of similarities between PDXOs and parental PDXs in genomics, histopathology and pharmacology, suggesting “biological equivalence or interchangeability” between the two. Here we demonstrate the applications of PDXO biobank for HTS “matrix” screening for both lead compounds and indications, immune cell co-cultures for immune-therapies and engineering enables in vitro/in vivo imaging. This large biobank of matched pairs of PDXs/PDXOs across different cancers could become powerful tools for the future cancer drug discovery.
Xiaoxi Xu, Shuzhong Wang, Jun Zhou, Jing Chen, Yujun Huang, Rajendra Kumari, Binchen Mao, Meiling Zheng, jingjing wang, Xiaolong Tu, Xiaoyu An, xiaobo chen, Likun Zhang, Xiaoli Tian, haojie Wang, Xin Dong, Zheng‐Zheng Bao, Sheng Guo, Xuesong Ouyang, Limei Shan, Fei Wang, Xuefei Yan, zhongliang li, Rui Zhang, hongjuan zhang, svenjer meiler, Robert Vries, Hans Clevers, Qi‐Xiang Li (2020). A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology. , DOI: https://doi.org/10.21203/rs.3.rs-63366/v1.
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Type
Preprint
Year
2020
Authors
29
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.21203/rs.3.rs-63366/v1
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