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Get Free AccessResults: Cohort1 (253 patients) included undifferentiated pleomorphic sarcoma (UPS), myxofibrosarcoma (MFS), synovial sarcoma (SS), leiomyosarcoma (LMS), dedifferentiated liposarcoma (DDLPS) and malignant peripheral nerve sheath tumor (MPNST).12 % (31/253) exhibited amp of NECTIN4.The UPS group comprised 50 cases with 11 (22%) with amp.For MFS amp was observed in 5 out of 25 cases (20%).For 100 LMS cases, 5 (5%) had the amp.Among 59 DDLPS samples, 8 presented the amp (13%).Only 1 case in the SS group, out of 10 cases analyzed, exhibited amp.No amp was observed in the MPNST group (9 cases).Cohort 2 consisted of 2,922 samples across 38 cancers.The STS collection consisted of 34 cases, including 19 cases of DDLPS, with 16% (3/19) showing amp, and 15 cases of LMS, with an amp rate of 7%.Conclusions: Our findings underscore the need for further investigation of Nectin-4 in STS, including immunohistochemical analysis and clinical trials with ADCs such as Enfortumab-vedotin, emphasizing the potential of cutting-edge therapies to improve outcomes in sarcomas.
N. Penel, S. Bonvalot, J. Elices-Diez, A. Italiano, B. Verret, Jenny Kurtz, Pascale Dubray‐Longeras, C. Guillemet, F. Duffaud, François Bertucci, J. Thery, Marie Vanseymortier, E. Bompas, Nelly Firmin, P. Boudou Rouquette, Jennifer Wallet, Sophie Piperno‐Neumann, Thibaud Valentin, Jean Yves Blay, M. Le Deley (2025). 88P Head, neck and shoulder desmoid-type fibromatosis: characteristics and outcome of these ultra-rare locations. , 10, DOI: https://doi.org/10.1016/j.esmoop.2025.104401.
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Type
Article
Year
2025
Authors
20
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1016/j.esmoop.2025.104401
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