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Get Free AccessKnockout of the oxygen-sensor HIF prolyl hydroxylase 1 (PHD1) was shown to switch metabolism towards glycolysis and reduced cellular oxygen consumption. As we recently showed a pro-atherosclerotic effect of plaque hypoxia, we hypothesised that reduced cellular oxygen consumption in PHD1 knockout mice alleviates atherosclerosis development.
Elke Marsch, Jasper A. F. Demandt, Thomas Theelen, MJ Gijbels, Patrick C.N. Rensen, Peter Carmeliet, Edward A. Fisher, EAL Biessen, MJAP Daemen, Judith C. Sluimer (2014). 13PHD1 deficiency promotes an atheroprotective metabolic phenotype. , 103(suppl 1), DOI: https://doi.org/10.1093/cvr/cvu075.3.
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Type
Article
Year
2014
Authors
10
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1093/cvr/cvu075.3
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