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Discovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics
Dale L. Boger, Hiroshi Miyauchi, Wu Du, Christophe Hardouin, Robert Fecik, Heng Cheng, Inkyu Hwang, Michael P. Hedrick, Donmienne Leung, Orlando Acevedo, Cristiano R. W. Guimarães, William L. Jorgensen, Benjamin F. Cravatt (2004). Discovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics. Journal of Medicinal Chemistry, 48(6), pp. 1849-1856, DOI: 10.1021/jm049614v.
Article399 days agoEnergetic Preferences for α,β versus β,γ Unsaturation
Patrick S. Lee, Wu Du, Dale L. Boger, William L. Jorgensen (2004). Energetic Preferences for α,β versus β,γ Unsaturation. The Journal of Organic Chemistry, 69(16), pp. 5448-5453, DOI: 10.1021/jo049363y.
Article399 days ago