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The last 5 uploaded publications
IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis
Peng Zhang, Junlai Liu, Allen Lee, Irene Tsaur, Masafumi Ohira, Vivian Duong, Nicholas Vo, Kosuke Watari, Hua Su, Ju Youn Kim, Li Gu, Mandy Zhu, Shabnam Shalapour, Mojgan Hosseini, Gautam Bandyopadhyay, Su-Ling Zeng, Cristina Llorente, Haoqi Nina Zhao, Santosh Lamichhane, Siddharth Mohan, Pieter C. Dorrestein, Jerrold M. Olefsky, Bernd Schnabl, Pejman Soroosh, Michael Karin (2024). IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis. , 36(10), DOI: https://doi.org/10.1016/j.cmet.2024.08.012.
Article58 days agoIL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease
Hsiao-Yen Ma, Gen Yamamoto, Jun Xu, Xiao Liu, Daniel Karin, Ju Youn Kim, Ludmil B. Alexandrov, Yukinori Koyama, Takahiro Nishio, Christopher Benner, Sven Heinz, Sara Brin Rosenthal, Shuang Liang, Mengxi Sun, Gabriel Karin, Peng Zhao, Pnina Brodt, Iain H. McKillop, Oswald Quehenberger, Edward A. Dennis, Alan R. Saltiel, Hidekazu Tsukamoto, Bin Gao, Michael Karin, David A. Brenner, Tatiana Kisseleva (2019). IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. , 72(5), DOI: https://doi.org/10.1016/j.jhep.2019.12.016.
Article58 days agoER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P
Ju Youn Kim, Ricard Garcia‐Carbonell, Shinichiro Yamachika, Peng Zhao, Debanjan Dhar, Rohit Loomba, Randal J. Kaufman, Alan R. Saltiel, Michael Karin (2018). ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. , 175(1), DOI: https://doi.org/10.1016/j.cell.2018.08.020.
Article58 days agoElevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death
Ricard Garcia‐Carbonell, Jerry Wong, Ju Youn Kim, Lisa Abernathy‐Close, Brigid S. Boland, Thomas L. Wong, Philip A. Harris, Samuel B. Ho, Soumita Das, Peter B. Ernst, Roman Šášik, William J. Sandborn, John Bertin, Pete J. Gough, John T. Chang, Michelle A. Kelliher, David L. Boone, Mónica Gumà, Michael Karin (2018). Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.
Article58 days agoElevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death
Ricard Garcia‐Carbonell, Jerry Wong, Ju Youn Kim, Lisa Abernathy‐Close, Brigid S. Boland, Thomas L. Wong, Philip A. Harris, Samuel B. Ho, Soumita Das, Peter B. Ernst, Roman Šášik, William J. Sandborn, John Bertin, Pete J. Gough, John T. Chang, Michelle A. Kelliher, David L. Boone, Mónica Gumà, Michael Karin (2018). Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. , 115(39), DOI: https://doi.org/10.1073/pnas.1810584115.
Article58 days ago