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Get Free AccessThe longitudinal cognitive trajectory in pediatric-onset MS has a heterogeneous course over time, with a decline in the first years followed by a partial recovery over the long term. However, at the last follow-up evaluation, the proportion of impaired patients was more than double compared with baseline, with a negative impact on the individual's socioprofessional attainment in adulthood. This study underscores how cognitive reserve may partially mitigate the negative effects of brain damage, highlighting the critical importance of intellectual enrichment early during the disease course.
Emilio Portaccio, Angelo Bellinvia, Lorenzo Razzolini, Luisa Pastò, Benedetta Goretti, Claudia Niccolai, Mattia Fonderico, Mauro Zaffaroni, Lorena Pippolo, Lucia Moiola, Monica Falautano, Claudia Celico, Rossella Viterbo, Francesco Patti, Clara Grazia Chisari, Paolo Gallo, Alice Riccardi, Martina Borghi, Antonio Bertolotto, Marta Simone, Carlo Pozzilli, Valentina Bianchi, Marco Roscio, Vittorio Martinelli, Giancarlo Comi, Massimo Filippi, María Trojano, Angelo Ghezzi, Maria Pia Amato (2022). Long-term Cognitive Outcomes and Socioprofessional Attainment in People With Multiple Sclerosis With Childhood Onset. , 98(16), DOI: https://doi.org/10.1212/wnl.0000000000200115.
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Type
Article
Year
2022
Authors
29
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1212/wnl.0000000000200115
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